176 FETAL SHEEP PLASMA INSULIN CONCENTRATION AND UMBILICAL LACTATE UPTAKE
نویسندگان
چکیده
منابع مشابه
Simultaneous measurements of lactate turnover rate and umbilical lactate uptake in the fetal lamb.
Lactic acid represents a major exogenous nutrient for the developing fetal lamb in utero. Our study was undertaken (a) to quantitate the net consumption of lactate by the fetus, (b) to quantitate the net lactate production and metabolism by the placenta, and (c) to compare the net fetal lactate consumption with fetal lactate use, measured simultaneously with radioactive tracers. 14 pregnant she...
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The ontogeny and developmental control of plasma leptin concentration in the fetus are poorly understood. The present study investigated plasma leptin concentration in chronically catheterized sheep fetuses near term, and in neonatal and adult sheep. The effect of glucocorticoids on plasma leptin in utero was examined by fetal adrenalectomy and exogenous cortisol or dexamethasone infusion. In i...
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It has been suggested that the foetus of a diabetic mother is subjected to intermittent hyperglycaemia and that this is followed by pancreatic islet hyperplasia, increased insulin secretion, and greater deposition of fat (Osler, 1960). Measurements of plasma-insulin-like activity in the newborn in response to a glucose load have shown that the baby of a diabetic mother has a greater rise of ins...
متن کاملRelationship of fetal alanine uptake and placental alanine metabolism to maternal plasma alanine concentration.
Uterine and umbilical uptakes of alanine (Ala) were measured in 10 ewes before (control) and during intravenous infusion of Ala, which increased maternal arterial Ala concentration from 115 ± 14 to 629 ± 78 μM ( P < 0.001). In 8 of these ewes, placental Ala fluxes were traced by constant intravenous infusion ofl-[3,3,3-2H3]Ala in the mother andl-[1-13C]Ala in the fetus. Rates are reported as mi...
متن کاملUmbilical uptake of amino acids in the unstressed fetal lamb.
The whole blood concentrations of 22 amino acids were measured in a chronic, unstressed fetal lamb preparations. Samples were taken daily from the umbilical artery, umbilical vein, and maternal artery over the latter quarter of gestation. 73 sets of samples (from the umbilical artery and vein and the maternal artery) from 13 animals were analyzed for amino acid levels. Oxygen contents were dete...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1978
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-197804001-00181